Descending pain modulation: influence and impact
نویسندگان
چکیده
منابع مشابه
Nicotinic modulation of descending pain control circuitry.
Along with the well-known rewarding effects, activation of nicotinic acetylcholine receptors (nAChRs) can also relieve pain, and some nicotinic agonists have analgesic efficacy similar to opioids. A major target of analgesic drugs is the descending pain modulatory pathway, including the ventrolateral periaqueductal gray (vlPAG) and the rostral ventromedial medulla (RVM). Although activating nAC...
متن کاملpain and modulation processes
pain is one of the most important and sometimes difficult problems, that patients and physicians are encountered. it may be clinically acute or chronic, acute pain has usually definite cause and favourable response to treatment. on the other hand there are difficulties in diagnosis and management of chronic pain. peripheral and cranial nerves convey pain impulses toward central nervous system, ...
متن کاملDescending control of pain.
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling) information from the viscera, skin and other organs is subject to extensive processing by a diversity of mechanisms, certain of which enhance, and certain of which inhibit, its transfer to higher centres. In this regard, a network of descending pathways projecting from cerebral structures to the DH plays a co...
متن کاملDescending control of pain.
Thanks largely to the study of the brainstem nuclei that mediate stimulation analgesia, the involvement of the monoamines in the descending control of pain is now well established. The periaqueductal grey, the raphe nuclei (NRM and DRN) and the locus coeruleus are all key brainstem sites for the control of nociceptive transmission in the spinal cord. Although the initial emphasis was on 5-HT as...
متن کاملInfluence of ketamine and morphine on descending pain modulation in chronic pain patients: a randomized placebo-controlled cross-over proof-of-concept study.
BACKGROUND Descending inhibition of pain, part of the endogenous pain modulation system, is important for normal pain processing. Dysfunction is associated with various chronic pain states. Here, the effect of ketamine and morphine on descending inhibition is examined using the conditioned pain modulation (CPM) paradigm in chronic neuropathic pain patients. METHODS CPM responses were obtained...
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ژورنال
عنوان ژورنال: Current Opinion in Physiology
سال: 2019
ISSN: 2468-8673
DOI: 10.1016/j.cophys.2019.06.004